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Hypertension in Pregnancy Volume 40, 2021 - Issue 2
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Research Article

Unraveling the role of oxidative stress and lipid status parameters in the onset of preeclampsia

Petar Cabunaca Department of High-Risk Pregnancy, Clinic of Gynecology and Obstetrics “Narodni Front”, Belgrade, SerbiaCorrespondence[email protected]
,
Nataša Karadžov Orlića Department of High-Risk Pregnancy, Clinic of Gynecology and Obstetrics “Narodni Front”, Belgrade, Serbia;b Faculty of Medicine, University of Belgrade, Belgrade, Serbia
,
Daniela Ardalićc Department of Medical Biochemistry, Clinic of Gynecology and Obstetrics “Narodni Front”, Belgrade, Serbia
,
Gorica Banjacc Department of Medical Biochemistry, Clinic of Gynecology and Obstetrics “Narodni Front”, Belgrade, Serbia
,
Jasmina Ivaniševićd Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
,
Jelena Janaćd Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
,
Jelena Vekićd Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
,
Aleksandra Zeljkovićd Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
,
Marija Mihajlovićd Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
,
Nina Rajoviće Institute for Medical Statistics and Informatics, University of Belgrade, Belgrade, Serbia
,
Nataša Miliće Institute for Medical Statistics and Informatics, University of Belgrade, Belgrade, Serbia;f Division of Nephrology and Hypertension, Mayo Clinic, Rochester, USA
&
Željko Mikovića Department of High-Risk Pregnancy, Clinic of Gynecology and Obstetrics “Narodni Front”, Belgrade, Serbia;b Faculty of Medicine, University of Belgrade, Belgrade, Serbia
 show all
Pages 162-170 | Received 12 Oct 2020, Accepted 20 Apr 2021, Published online: 03 May 2021
 
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ABSTRACT

OBJECTIVE: The aim of the study was to assess the potential role of oxidative stress and lipid status in the onset of preeclampsia.

METHODS: 138 high-risk pregnant women were prospectively followed. Assessment of oxidative stress (TAS, TOS, AOPP and SH groups) and lipid status (t-C, LDL-C, HDL-C, TGC, APO-A1, APO-B) was carried out during the pregnancy.

RESULTS: 30 women developed preeclampsia. TGC, atherogenic index of plasma, TAS and SH levels were higher in women who subsequently developed preeclampsia (p<0.05).

CONCLUSION: Oxidative stress and lipid status disturbance have a potential role in the onset of preeclampsia in high risk pregnancies.

Disclosure statement

No potential conflict of interest was reported by the author(s).

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