Predictive value of the sFlt-1/PlGF ratio for preeclampsia in twin pregnancies: a retrospective study

ABSTRACT

Objective: This study aimed to investigate the efficiency of the soluble Fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio in predicting preeclampsia (PE) within 4 weeks in twin pregnancies.

Methods: Seventy-eight women with serum angiogenic markers measured at 28 + 0 to 30 + 6 weeks of gestation were enrolled. A receiver-operating characteristic curve was used to determine the sFlt-1/PlGF ratio threshold to predict PE.

Results: A cutoff value for the sFlt-1/PlGF ratio of 22.2 predicted PE presence within 4 weeks.

Conclusion: An sFlt-1/PlGF ratio of ≤22.2 is potentially indicative of PE absence within 4 weeks in twin pregnancies.

KEYWORDS:

• Twin pregnancy
• preeclampsia
• fms-like tyrosine kinase-1
• placental growth factor
• predicting factor

Acknowledgments

We thank the study subjects for allowing us the use of their personal data. We would also like to thank Editage (www.editage.com) for English language editing.

Disclosure statement

The authors report no conflict of interest.

Data availability statement:

All data relevant to the study are included in the article.

Additional information

Funding

The authors declare that this study did not receive any specific grant for this research from any funding agency in the public, commercial, or not-for-profit sectors.