MiR-125b-5p ameliorates hypoxia/reoxygenation-induced endothelial cell dysfunction and attenuates reduced uterine perfusion pressure-induced hypertension in pregnant rats via targeting BMF

ABSTRACT

Background and Purpose

MicroRNA-125b-5p (miR-125b-5p) is downregulated in patients with gestational hypertension signs. However, the role of miR-125b-5p in pregnancy-induced hypertension (PIH) remains unknown.

Methods

The human placental microvascular endothelial cells (HPMECs) have undergone hypoxia and reoxygenation (H/R) treatment to establish PIH cellular model. Rats were performed with reduced uterine perfusion pressure (RUPP) operation to establish PIH animal model.

Results

MiR-125b-5p promoted viability while inhibited the apoptosis of H/R-treated HPMECs by downregulating BMF. MiR-125b-5p alleviated hypertensive symptoms and improved pregnancy outcomes in RUPP rats.

Conclusion

MiR-125b-5p ameliorates H/R-induced HPMEC dysfunction and attenuates RUPP-induced hypertension in pregnant rats by downregulating BMF.

KEYWORDS:

• miR-125b-5p
• BMF
• human placental microvascular endothelial cells
• pregnancy-induced hypertension

Acknowledgments

Not applicable.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Consent for publication

Not applicable.

Ethics approval and consent to participate

All institutional and national guidelines for the care and use of laboratory animals were followed.

Data availability statement

The data underlying this article will be shared on reasonable request to the corresponding author.

Additional information

Funding

The author(s) reported that there is no funding associated with the work featured in this article.