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Clinical and Experimental Hypertension Volume 31, 2009 - Issue 2
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Galectin-2 (LGALS2) 3279C/T Polymorphism may be Independently Associated with Diastolic Blood Pressure in Patients with Rheumatoid Arthritis

Vasileios F. Panoulas Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK; Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, GreeceCorrespondence[email protected]
,
Karen M.J. Douglas Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK
,
Jacqueline P. Smith Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK; Department of Clinical Biochemistry, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK
,
Georgios S. Metsios Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK
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Moses S. Elisaf Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece
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Peter Nightingale Wolfson Computer Laboratory, University Hospital Birmingham, NHS Foundation Trust, Birmingham, UK
&
George D. Kitas Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK; Arthritis Research Campaign, Epidemiology Unit, Manchester University, Manchester, UK
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Pages 93-104 | Received 02 Mar 2008, Accepted 01 Jun 2008, Published online: 03 Jul 2009
 
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Abstract

The galectin-2 (LGALS2) 3279 C/T single nucleotide polymorphism (SNP) has recently been associated with myocardial infarction (MI). Although hypertension, a very prevalent entity in rheumatoid arthritis (RA), is one of the greatest risk factors for MI, the possible association of LGALS2 3279 C/T and hypertension has not been investigated. We genotyped 386 RA patients, 272 hypertensives and 114 normotensives. Diastolic blood pressure (DBP) was significantly lower in TT compared to CC homozygotes (−4.11 mmHg, p = 0.044) even when adjusted for multiple confounders (−4.28 mmHg, p = 033). Further studies are required to replicate the potential association of LGALS2 3279 C/T with DBP, and examine whether this SNP could be used as a marker of increased risk for future cardiovascular events in RA populations.

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