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Clinical and Experimental Hypertension Volume 31, 2009 - Issue 4
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Is Prehypertension Really Different from Normotension and Hypertension? A Case-Control Pilot Proteomic Study in Chinese

Zuoguang Wang Department of Hypertension, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, PR, China
,
Xiaoyun Peng Institute of Westnorth Plateau Biology, China Academy of Sciences, PR, China
,
Yanduo Tao Institute of Westnorth Plateau Biology, China Academy of Sciences, PR, China
,
Ya Liu Department of Hypertension, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, PR, China
,
Jieling Liu Department of Hypertension, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, PR, China
,
Xingjun Chen Department of Hypertension, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, PR, China
,
Shaojun Wen Department of Hypertension, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, PR, ChinaCorrespondence[email protected]
&
Zhaosu Wu Department of Cardiovascular Epidemiology, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing, PR, China
 show all
Pages 316-329 | Received 18 Sep 2008, Accepted 29 Oct 2008, Published online: 19 Sep 2009
 
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Abstract

This study was designed to investigate the differences in the plasma proteome of healthy normotensive, prehypertensive, and hypertensive subjects. A case-control pilot study was conducted among well-matched subjects. Plasma protein was analyzed by two-dimensional electrophoresis combined with MALDI-TOF mass spectrometry. The results showed that there were 22 differentially expressed spots among the three groups, which corresponded to 18 proteins involved in inflammation and immunity, lipid metabolism, transport, coagulation and fibrinolysis, cell proliferation and apoptosis, and anti-oxidation. With an increase in blood pressure, these proteins were differentially expressed which indicated that prehypertension probably was an early stage of hypertension.

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