Polymorphism-801G/A in the 3′-untranslated region of CXCL12 is not associated with preeclampsia in Chinese Han population

ABSTRACT

Objective: We investigated whether the CXCL12-801G/A polymorphism was associated with preeclampsia (PE) susceptibility in a Chinese Han population. Methods: We examined 912 PE women and 1025 controls for the CXCL12-801G/A polymorphism by polymerase chain reaction (PCR) and correlations with clinical characteristics were examined. Results: No significant differences in genotypic and allelic frequencies of CXCL12-G801A were found between cases and controls (genotype: χ² = 2.095, p = 0.351; allele: χ² = 1.713, p = 0.191). There were also no significant differences between early/late-onset or mild/severe PE and control groups. Conclusion: The results indicate that 801G/A in CXCL12 may not play a major role in pathogenesis of PE in a Chinese Han population.

KEYWORDS:

• CXCL12
• pathogenesis
• polymorphism
• preeclampsia
• susceptibility

Acknowledgments

We are grateful to all participants who have made the completion of this study.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.