Effect of antihypertensive drugs on breast cancer risk in female hypertensive patients: Evidence from observational studies

ABSTRACT

This systematic review aimed to evaluate the association between antihypertensive drugs and risk of breast cancer, and provide therapeutic implications for female hypertensive patients with different physical appearance. The prevalence of hypertension and female breast cancer is on the rise with age. It has been suggested that ARBs (angiotensin receptor blockers), ACEi (angiotensin-converting enzyme inhibitor), CCBs (calcium channel blockers), and BBs (beta-blockers) were widely used in hypertensive patients. Some researches have shown ARBs, ACEis, and beta-blockers to be effective drugs for blood pressure lowering as well as for reducing the risk of breast cancer in women. However, the research conclusions were inconsistent. To address the conflicting evidence from previous study, the study evaluates the risk of breast cancer in hypertensive women. In conclusion, we report the evidence that beta-blockers can reduce the risk of breast cancer recurrence, while ACEi and CCBs were not associated with an increased risk of breast cancer.

KEYWORDS:

• Angiotensin-converting enzyme inhibitor
• angiotensin receptor blocker
• antihypertensive drugs
• beta-blockers
• breast cancer

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Funding

This study was supported by the foundation of Lanzhou University Second Hospital (ynbskyjj2015-1-11, ynbskyjj2015-2-1).

Additional information

Funding

This study was supported by the foundation of Lanzhou University Second Hospital (ynbskyjj2015-1-11, ynbskyjj2015-2-1).