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ABSTRACT
Background: Increased arterial stiffness is an independent cardiovascular risk factor in smokers or patients with diabetes mellitus and hypertension. Cardio-ankle vascular index (CAVI) is an index of arterial stiffness and atherosclerosis. One of the most important risk factors of the causes of atherosclerosis is dyslipidemia(DLP). However, there was a little research about which influence factors such as: hypertension, diabetes mellitus, and smoking could contribute to the atherosclerosis in the subjects withDLP. Methods: A total of 649 subjects with DLP (Male328/Female321) from Vascular Medicine of Peking University Shougang Hospital were examined, with a median age of 66 and 5–95 percentile range 47.0–83.5 years. Fasting plasma glucose (FPG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), triglyceride (TG) were analyzed by colorimetric enzymatic assays with the use of an auto analyzer (HITACHI-7170, Hitachi, Tokyo, Japan).CAVI was measured by VS-1000 apparatus. Results: CAVI correlated significantly with age (p<0.001), Systolic (p<0.001) blood pressure(BP), Total cholesterol (p<0.001), LDL-cholesterol (p<0.001),Triglycerides (p<0.001) . There was no significant difference in CAVI between smokers and non-smokers (p = 0.08) and between statin-treated subjects than in those without statins (p = 0.247). CAVI was significantly higher in subjects with hypertension than in the normotensive group (p<0.001) and in mellitus subjects than in those without mellitus (p<0.001);however, CAVI values adjusted for age was higher only in hypertension than in the normotensive group (p<0.001). Conclusions: Our study demonstrated that CAVI value in DLP patients is not significantly affected by diabetes mellitus and smoking, but is increased by hypertension.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.
Ethics approval
Ethics approval has been granted from the ethics committee of Peking University Shougang Hospital.
Funding
This value work was supported by grants from the National Key Scientific Research Projects (No. 2017YFC0113005), Beijing health and health science and technology achievement and appropriate technology extension project (No. TG-2017-66), the hospital fund of Peking University Shougang Hospital to Hongyu Wang (No. 2017- Hospital-Clinical -01), the major project fund Peking University Shougang Hospital to Hongyu Wang (No. SGYYZ201610), Beijing Chinese medicine science and Technology Development Fund Project (No. NQ2016-07);Hongyu Wang [2010Y002];Jinbo liu [2012Y04];Beijing health and health science and technology achievement and appropriate technology extension project [TG-2017-66];he hospital fund of Peking University Shougang Hospital to Hongyu Wang [he hospital fund of Peking University Shougang Hospital to Hongyu Wang];Beijing Chinese medicine science and Technology Development Fund Project [NQ2016-07];he National Key Scientific Research Projects [2017YFC0113005].