APOA5 rs651821 confers increased risk for hypertension in Tongdao Dong population

ABSTRACT

Hypertension is a complex disease that partially influenced by genetic factors. Up till now, the association between the rs651821 in apolipoprotein A5 (APOA5) gene and hypertension remains unknown. This study was undertaken to investigate the relationship between the APOA5 rs651821 and hypertension in Tongdao Dong population. A total of 274 participants were involved in this study (135 hypertensive patients and 139 nonhypertensive adults). The single nucleotide polymorphism (SNP) was genotyped by using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The results showed that the genotypic and allelic frequencies of rs651821 were significantly different between the normotensives and hypertensive subjects (P = 0.009, P = 0.003 respectively). TC/CC genotypes of rs651821 were associated with an elevated risk of hypertension (TC/CC vs. TT: adjusted odds ratio (AOR) = 1.791, 95%CI = 1.067–3.006, P = 0.009). Besides, the TC/CC genotypes were related to an increased plasma triglyceride (TG) level (TC/CC vs. TT: 2.47 ± 1.91 vs. 1.82 ± 1.07, P = 0.001).The results suggest that the C carriers of APOA5 rs651821 are associated with an increased serum TG concentration and may cause the increased susceptibility of the individual to hypertension in Chinese Dong population.

KEYWORDS:

• APOA5
• SNP
• rs651821
• hypertension
• association

Acknowledgments

This study was financially supported by the Research Project of Hunan Province Education Department (No.17C1150) and College Students’ Learning and Innovation Experimental Project of Hunan Province (No.201612214005).

Author Contributions

Xinglin Jiang, Haiying Wang and Taimei Zhou designed the study and recruited the subjects and collected the data. Huiying He, Rong Peng and Sujie Wang performed the experiments. Huiying He and Rong Peng accomplished data analysis. Haiying Wang, Taimei Zhou and Huiying He wrote the paper. Xinglin Jiang reviewed and edited the manuscript. All authors read and approved the manuscript.

Conflict of Interest

The authors declare they have no competing financial interests.

Additional information

Funding

This study was financially supported by Scientific Research Fund of Hunan Provincial Education Department (No.17C1150) and College Students’ Learning and Innovation Experimental Project of Hunan Province (No.201612214005).