Investigation heme oxygenase-1 polymorphism with the pathogenesis of preeclampsia

ABSTRACT

Objectives: The involvement of oxidative stress in the pathophysiology of preeclampsia (PE) has been already suggested. In this present study, we aimed to investigate the association of the genetic frequency of heme oxygense-1 (HMOX1) polymorphism with PE in Chinese Han women.

Methods: We researched the genetic distribution of rs2071746 polymorphism in HMOX1 by the TaqMan allelic discrimination real-time PCR between 1235 PE patients and 1720 healthy women.

Results: We found there were′t significant differences in the distribution of HMOX1 rs2071746 polymorphism in PE compared to the control group (rs2071746, genotype χ² = 0.282, P = 0.869 and allele χ² = 0.027, P = 0.869, OR = 1.009, 95% = 0.909–1.120).

Conclusion: The rs2071746 polymorphism in HMOX1 might not be related to PE in Chinese women, although further investigations should be conducted to confirm our findings.

KEYWORDS:

• HMOX1
• pathogenesis
• polymorphism
• preeclampsia
• oxidative stress

Acknowledgments

We thank all participants who have made efforts for the study. This project was supported by the National Natural Science Foundation of China (81371499 and 301.hjh.00001586).

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [81371499 and 30971586].