Abstract
Nowadays the in silico scenario for drug design is totally dependent on structural biology and structural bioinformatics. A myriad of free bioinformatics applications and services have been posted on the web. This mini-review mentions web sites that are useful in structure-based drug design. The information is given in a logical manner, following the drug design process i.e. characterization of a protein target, modelling the protein using sequence homology, optimization of the protein structure and finally docking of small ligands into the active site.
† Presented at CMTPI 2005: Computational Methods in Toxicology and Pharmacology integrating Internet Resources (Shanghai, China, October 29–November 1, 2005).
Notes
† Presented at CMTPI 2005: Computational Methods in Toxicology and Pharmacology integrating Internet Resources (Shanghai, China, October 29–November 1, 2005).
* There is some confusion about the meaning of “open source”. At the beginning of software development, most scientific software source code was free and open with a minimum of formalities. These days, it appears that carefully drawn legal documents are necessary to protect free access to the source code of scientific software.