Preparation and characterization of GRGDY modified poly(dl-lactic acid)/hydroxyapatite porous composite

Abstract

A novel modified poly(DL-lactic acid) (PDLLA) was obtained by covalent grafting of maleic anhydride, hexanediamine and GRGDY onto the backbone of PDLLA to improve the hydrophilicity of PDLLA; Then, the modified PDLLA/HA porous composite was prepared. The cell affinity and cell growth were improved. FTIR, ¹³C NMR, DSC, AAA and SEM were used to characterize the composite material. The hydrophilicity and interfacial compatibility of composite were tested

Keywords:

• PDLLA
• Grafting
• GRGDY
• HA
• Porous composite