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Materials Technology
Advanced Performance Materials
Volume 35, 2020 - Issue 2
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Research Articles

Development of glucosamine functionaliZed micelles as a potential drug delivery system for targeting to brain

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Pages 125-133 | Received 04 Jun 2019, Accepted 17 Aug 2019, Published online: 04 Sep 2019
 

ABSTRACT

The objective of this work was to develop micelles of D-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS), conjugated with glucosamine for non-invasive targeted delivery of curcumin (CRM) for tumour targeting. The micelles with and without glucosamine conjugation were prepared by the solvent casting method and characterised for their particle size, surface morphology, drug entrapment efficiency, drug loading and in vitro drug release study. The molecule sizes of the functionalised micelles were 189.9 nm and for non- functionalised micelles were146.8nm. Drug entrapment was found 98.19 ± 1.2% and 92.81 ± 1.4% with non- functionalised and t functionalised micelles respectively. The in vitro release revealed that curcumin stacked glucosamine TPGS micelles could be a promising bearer for tumour targeting due to nanosized medication delivery, which gave an enhanced and prolonged tumour targeting of curcumin.

Acknowledgments

One of the authors Dr Hitendra S Mahajan debited to University Grant Commission (UGC) New Delhi for financial assistance under Major Research Project (MRP) Scheme (F.No.43 −491/2014 (SR). Oct. 2015).

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the University Grants Commission [43 −491/2014 (SR).].

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