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Abstract
Oxidative stress has been related to ageing and risk of death. To determine whether oxidative status was associated with all-cause risk of death we carried out a prospective study in 154 non-smoking Spanish elderly without major illness. Baseline glutathione peroxidase (GPx) and superoxide dismutase (SOD) were analysed in plasma and erythrocytes. α-tocopherol, β-carotene, lycopene and retinol were determined in serum samples and malondialdehyde (MDA), as a lipid peroxidation marker, in plasma. Mean survival time was 4.3 years. A total of 31 death cases (20.1%) occurred during the follow-up. Plasma-MDA predicted mortality independently of all other variables, while erythrocyte-SOD (e-SOD), β-carotene and α-tocopherol were positively associated with survival. α-tocopherol and MDA were revealed as independent predictors in a joint survival model, being the group with low MDA and high α-tocopherol that with the lowest mortality. In conclusion, a higher risk of death was associated with increased lipid peroxidation and lower antioxidant defenses.
| Abbreviations | ||
| BMI | = | body mass index |
| DNA | = | deoxyribonucleic acid |
| e-GPx | = | erythrocyte-glutathione peroxidase |
| p-GPx | = | plasma-glutathione peroxidase |
| HPLC | = | high-performance liquid chromatography |
| MDA | = | malondialdehyde |
| e-SOD | = | erythrocyte-superoxide dismutase |
| p-SOD | = | plasma-superoxide dismutase |
| Abbreviations | ||
| BMI | = | body mass index |
| DNA | = | deoxyribonucleic acid |
| e-GPx | = | erythrocyte-glutathione peroxidase |
| p-GPx | = | plasma-glutathione peroxidase |
| HPLC | = | high-performance liquid chromatography |
| MDA | = | malondialdehyde |
| e-SOD | = | erythrocyte-superoxide dismutase |
| p-SOD | = | plasma-superoxide dismutase |