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Free Radical Research Volume 40, 2006 - Issue 12: Free Radicals in the Aging Process–The 'Free Radical Theory of Aging' 50 years after
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Original

Lipofuscin-like fluorophores originated from malondialdehyde

Koji Uchida Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, 464-8601, JapanCorrespondence[email protected]
Pages 1335-1338 | Received 29 May 2006, Published online: 07 Jul 2009
 
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Abstract

The accumulation of fluorescent age pigment or lipofuscin is a frequently observed age-associated cellular alteration in a variety of post-mitotic cells of many species. These pigments are observed within granules composed, in part, of damaged protein and lipid. In the present mini-review, I provide a comprehensive summary of fluorescent adducts originated from malondialdehyde (MDA).

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