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Abstract
Aged garlic extract (AGE) possesses multiple biological activities. We evaluated the protective effect of S-allyl cysteine (SAC), one of the organosulfur compounds of AGE, against carbon tetrachloride (CCl4)-induced acute liver injury in rats. SAC was administrated intraperitoneally (50–200 mg/kg). SAC significantly suppressed the increases of plasma ALT and LDH levels. SAC also attenuated histological liver damage. CCl4 administration induced lipid peroxidation accompanied by increases in the plasma malondialdehyde and hepatic 4-hydroxy-2-nonenal levels, and SAC dose-dependently attenuated these increases. The hepatic total level of hydroxyoctadecadienoic acid (HODE), a new oxidative stress biomarker, was closely correlated with the amount of liver damage. These results suggest that SAC decreased CCl4-induced liver injury by attenuation of oxidative stress, and may be a better therapeutic tool for chronic liver disease.
| Abbreviations | ||
| AGE | = | aged garlic extract |
| ALT | = | alanine aminotransferase |
| AST | = | aspartate aminotransferase |
| CCl4 | = | carbon tetrachloride |
| CCl3 | = | trichloromethyl radical |
| Cys | = | l-cysteine |
| GSH | = | glutathione |
| HNE | = | 4-hydroxy-2-nonenal |
| HODE | = | hydroxyoctadecadienoic acid |
| LDH | = | lactate dehydrogenase |
| LPO | = | lipid peroxide |
| MDA | = | malondialdehyde |
| NAC | = | N-acetyl cysteine |
| PMA | = | phorbol 12-myristate 13-acetate |
| ROS | = | reactive oxygen species |
| SAC | = | S-allyl cysteine |
| SAMC | = | S-allylmercaptocysteine |
| SOD | = | superoxide dismutase |
| SSA | = | sulfosalicylic acid |
| 8-iso-PGF2α | = | 8-iso-prostaglandin F2α |
| 8-OHdG | = | 8-hydroxy-2-deoxyguanosine |
| Abbreviations | ||
| AGE | = | aged garlic extract |
| ALT | = | alanine aminotransferase |
| AST | = | aspartate aminotransferase |
| CCl4 | = | carbon tetrachloride |
| CCl3 | = | trichloromethyl radical |
| Cys | = | l-cysteine |
| GSH | = | glutathione |
| HNE | = | 4-hydroxy-2-nonenal |
| HODE | = | hydroxyoctadecadienoic acid |
| LDH | = | lactate dehydrogenase |
| LPO | = | lipid peroxide |
| MDA | = | malondialdehyde |
| NAC | = | N-acetyl cysteine |
| PMA | = | phorbol 12-myristate 13-acetate |
| ROS | = | reactive oxygen species |
| SAC | = | S-allyl cysteine |
| SAMC | = | S-allylmercaptocysteine |
| SOD | = | superoxide dismutase |
| SSA | = | sulfosalicylic acid |
| 8-iso-PGF2α | = | 8-iso-prostaglandin F2α |
| 8-OHdG | = | 8-hydroxy-2-deoxyguanosine |