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Free Radical Research Volume 42, 2008 - Issue 7
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Original

Early lipoic acid intake protects retina of diabetic mice

Siv Johnsen-Soriano Fundación Oftalmológica del Mediterráneo, Valencia, Spain
,
Maria Garcia-Pous Fundación Oftalmológica del Mediterráneo, Valencia, Spain
,
Emma Arnal Departamento de Fisiología, Farmacología & Toxicología, Universidad CEU Cardenal Herrera, Valencia, Spain
,
Maria Sancho-Tello Fundación Oftalmológica del Mediterráneo, Valencia, Spain
,
Salvador Garcia-Delpech Servicio de Oftalmología, Hospital General Universitario, Valencia, Spain
,
Maria Miranda Departamento de Fisiología, Farmacología & Toxicología, Universidad CEU Cardenal Herrera, Valencia, Spain
,
Francisco Bosch-Morell Fundación Oftalmológica del Mediterráneo, Valencia, Spain; Departamento de Fisiología, Farmacología & Toxicología, Universidad CEU Cardenal Herrera, Valencia, Spain
,
Manuel Diaz-Llopis Servicio de Oftalmología, Hospital General Universitario, Valencia, Spain; Departament de Cirurgia, Universitat de València, Valencia, Spain
,
Amparo Navea Fundación Oftalmológica del Mediterráneo, Valencia, Spain
&
Francisco Javier Romero Fundación Oftalmológica del Mediterráneo, Valencia, Spain; Departamento de Fisiología, Farmacología & Toxicología, Universidad CEU Cardenal Herrera, Valencia, SpainCorrespondence[email protected]
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Pages 613-617 | Received 04 Jan 2008, Published online: 07 Jul 2009
 
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Abstract

The aim of this study was to test the effect of lipoic acid treatment on the retina after a short diabetic insult. Diabetes was induced by alloxan and mice were divided into sub-groups; control, diabetic, diabetic+insulin and all groups received±lipoic acid (100 mg/kg body weight) for 3 weeks. GSH content, MDA concentration, GPx activity were measured and electroretinograms (ERG) were recorded. Early administration of lipoic acid to diabetic mice prevented the statistically significant decreases of GSH content and GPx activity and normalized MDA concentration. Moreover, lipoic acid restored electroretinogram b-wave amplitude of diabetic animals to control values. Lipoic acid has a protective effect on the diabetic retina.

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