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Free Radical Research Volume 43, 2009 - Issue 7
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SOD3 R231G polymorphism associated with coronary artery disease and myocardial infarction. The Ludwigshafen Risk and Cardiovascular Health (LURIC) study

Tanja B. Grammer Synlab Center of Laboratory Diagnostics Heidelberg, Heidelberg, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, AustriaCorrespondence[email protected]
,
Wilfried Renner Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria
,
Michael M. Hoffmann Division of Clinical Chemistry, Department of Medicine, University Medical Center, Freiburg, Germany
,
Markus Kleber Synlab Center of Laboratory Diagnostics Heidelberg, Heidelberg, Germany
,
Brigitte M. Winkelhofer-Roob The Human Nutrition and Metabolism Research and Training Center Graz, Karl-Franzens University, Graz, Austria
,
Bernhard O. Boehm Division of Endocrinology and Diabetes, Department of Medicine, Ulm University, Germany
&
Winfried Maerz Synlab Center of Laboratory Diagnostics Heidelberg, Heidelberg, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria; Department of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany
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Pages 677-684 | Received 01 Apr 2009, Published online: 21 Jul 2009
 
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Abstract

This study examined the superoxide dismutase 3 (SOD3) R231G polymorphism in relation to the severity of coronary artery disease (CAD) and the risk of myocardial infarction (MI) in 3211 individuals; 94.4% of study participants were homozygous for SOD3 231RR and 5.5% were heterozygous for SOD3 231RG. The odds ratios of the RG and GG genotype (adjusted for age, gender and for conventional cardiovascular risk factors) were 2.02 (95% CI, 1.23–3.33, p=0.005) for the highest vs the lowest Friesinger coronary score and 1.40 (95% CI, 1.02–1.92, p=0.037) for MI, respectively. Further the SOD3 RG and GG genotype was associated with lower alpha-tocopherol levels than the wild type SOD3 RR genotype. It is concluded that the SOD3 231RG and GG genotype is associated with lower alpha-tocopherol levels and the severity of CAD and the risk of MI.

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