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Free Radical Research Volume 43, 2009 - Issue 7
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Original

Tempol reduces the therapeutic effect of cyclophosphamide on an experimental tumour model

Vasily I. Kaledin Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, , Novosibirsk, 630090, Russia
,
Nelly A. Popova Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, , Novosibirsk, 630090, Russia
,
Valery P. Nikolin Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, , Novosibirsk, 630090, Russia
,
Evdokia D. Vasilieva Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, , Novosibirsk, 630090, Russia
,
Igor A. Kirilyuk Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
&
Igor A. Grigor'ev Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, RussiaCorrespondence[email protected]
Pages 685-690 | Received 05 Feb 2009, Published online: 21 Jul 2009
 
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Abstract

The nitroxyl radical 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) is reported to elicite some effects on different biological models. This paper studied the influence of Tempol on the therapeutic action of an alkylating agent cyclophosphamide (CP) in the transplantable murine lymphosarcoma LS. When administered exactly before CP, Tempol exerted no influence on efficacy of the tumour therapy but significantly reduced it under a single or multiple preliminary injections 1–3 days before CP. This regimen of Tempol administration is found to elevate the activity of aldehyde dehydrogenase in the liver, the enzyme which is known to reduce the yield of the activated metabolite(s) of CP.

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