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Free Radical Research Volume 52, 2018 - Issue 11-12: SFRR Asia
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Review Article

The diverse role of TIGAR in cellular homeostasis and cancer

Ji GengDepartment of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, School of Pharmaceutical Sciences, Soochow University, Suzhou, PR China; View further author information
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Xiao YuanPathology Department, The First Affiliated Hospital of Soochow University, Suzhou, PR ChinaView further author information
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Mingzhen WeiDepartment of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, School of Pharmaceutical Sciences, Soochow University, Suzhou, PR China; View further author information
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Junchao WuDepartment of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, School of Pharmaceutical Sciences, Soochow University, Suzhou, PR China; View further author information
&
Zheng-Hong QinDepartment of Pharmacology and Laboratory of Aging and Nervous Diseases, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, School of Pharmaceutical Sciences, Soochow University, Suzhou, PR China; Correspondence[email protected]
View further author information
Pages 1240-1249 | Received 26 Dec 2017, Accepted 09 Jun 2018, Published online: 04 Oct 2018
 
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Abstract

TP53-induced glycolysis and apoptosis regulator (TIGAR) is a p53 target protein that plays critical roles in glycolysis and redox balance. Accumulating evidence shows that TIGAR is highly expressed in cancer. TIGAR redirects glycolysis and promotes carcinoma growth by providing metabolic intermediates and reductive power derived from pentose phosphate pathway (PPP). The expression of TIGAR in cancer is positively associated with chemotherapy resistance, suggesting that TIGAR could be a novel therapeutic target. In this review, we briefly presented the function of TIGAR in metabolic homeostasis in normal and cancer cells. Finally, we discussed the future directions of TIGAR research in cancer.

Disclosure statement

No conflict of interest to be declared.

Additional information

Funding

This work was supported by grants from the National Natural Science Foundation of China [Grant No. 81730092].

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