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Original Article

Resveratrol attenuates iron-induced toxicity in a chronic post-treatment paradigm in Caenorhabditis elegans

, &
Pages 939-951 | Received 08 Sep 2017, Accepted 18 Jun 2018, Published online: 11 Sep 2018
 

Abstract

There is an increase in the number of studies indicating that a disturbance in iron homeostasis is involved in the pathogenesis of neurodegenerative diseases, in which oxidative stress plays an important role. Oxidative stress can be counteracted by bioactive molecules like the flavonoid resveratrol, which acts as scavenging agent, or by modulating enzymes and metabolic signalling pathways, thus depicting the neuroprotective potential. On the other hand, flavonoids, resveratrol included, have been reported to induce an increase in the reactive species production. In this study we aimed to evaluate in vivo the protective potential of resveratrol against iron imbalance using the Caenorhabditis elegans model. We acutely exposed C. elegans to iron and administered resveratrol pre- or post-iron treatment. Iron-treated worms demonstrated a significant decrease in the survival, neuronal change, decreased dehydrogenases activity and ATP levels, and a significant increase in the oxidative stress. Acute pre-exposure to resveratrol potentiated the toxic effect of the metal by reducing ATP levels, while post-iron chronic resveratrol treatment following the iron exposure increased the worms’ survival and reduced the generation of reactive species and neuronal damage. In conclusion, our results demonstrated that resveratrol has various protective effects depending on the duration and order of administration, whereby chronic post-iron treatment to resveratrol as an antidote appeared to be a more effective approach.

Acknowledgments

Authors would like to thank Ms. Catherine Au for her careful revision and suggestions.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by CNPq (Universal Grants), FAPERGS (PRONEM- Rede Gaúcha de Métodos Alternativos) and UNIPAMPA. M.V.S received PROBIC/FAPERGS undergraduate scholarship. DSA is the recipient of researcher fellowship (PQ2/CNPq).

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