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Articles

Strengthening controls on Novichoks: a family-based approach to covering A-series agents and precursors under the chemical-weapons nonproliferation regime

Pages 95-113 | Published online: 15 Feb 2022
 

ABSTRACT

Novichoks, also known as A-series agents, are nerve agents developed in the Soviet Union during the Cold War. Once obscure chemicals, they garnered a great deal of attention after their employment in the attempted assassinations of Sergei and Yulia Skripal in 2018 and of Alexei Navalny in 2020. Novichok agents were not originally featured in the schedules of the Chemical Weapons Convention (CWC), which are intended to support the treaty’s verification regime and declaration requirements. However, following the Skripal incident, the CWC schedules were amended to include Novichok agents. Furthermore, precursors for their synthesis were added to the Australia Group’s (AG) list of chemical-weapons precursors. In this article, we evaluate the recent revisions of the CWC schedules and the AG precursors list, identify the remaining weaknesses of both lists, and make recommendations for further amendments. We recommend strengthening the coverage of the CWC schedules by adding families of Novichok agents with guanidine branches. This is particularly important in light of the Navalny incident, since that incident appears to have involved a guanidine-bearing Novichok agent currently not covered by the CWC schedules. We also propose an approach to the control of Novichok precursors by the CWC and the AG based on families of chemicals rather than individually enumerated chemicals.

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1 Stefano Costanzi and Gregory D. Koblentz, “Controlling Novichoks after Salisbury: Revising the Chemical Weapons Convention Schedules,” Nonproliferation Review, Vol. 26, Nos. 5–6 (2019), pp. 1–14; Stefano Costanzi and Gregory D. Koblentz, “Updating the CWC: How We Got Here and What Is Next,” Arms Control Today, April 2020, pp. 16–20, <www.armscontrol.org/act/2020-04/features/updating-cwc-we-got-here-what-next>; Elspeth J. Hulse, James D. Haslam, Stevan R. Emmett, and Tom Woolley, “Organophosphorus Nerve Agent Poisoning: Managing the Poisoned Patient,” British Journal of Anaesthesia, Vol. 123, No. 4 (2019), pp. 457–63.

2 David Steindl et al., “Novichok Nerve Agent Poisoning,” The Lancet, Vol. 397, No. 10270 (2021), pp. 249–52; OPCW Technical Secretariat, “Summary of the Report on Activities Carried out in Support of a Request for Technical Assistance by Germany (Technical Assistance Visit – TAV/01/20),” S/1906/2020, June 10, 2020, <www.opcw.org/sites/default/files/documents/2020/10/s-1906-2020%28e%29.pdf>.

3 Vil S. Mirzayanov, State Secrets: An Insider’s Chronicle of the Russian Chemical Weapons Program (Denver, CO: Outskirts Press, 2009), pp. 142–49.

4 Hulse et al., “Organophosphorus Nerve Agent Poisoning”; Stefano Costanzi, John-Hanson Machado, and Moriah Mitchell, “Nerve Agents: What They Are, How They Work, How to Counter Them,” ACS Chemical Neuroscience, Vol. 9, No. 5 (2018), pp. 873–85.

5 Mirzayanov, State Secrets.

6 Lars Carlsen, “After Salisbury Nerve Agents Revisited,” Molecular Informatics, Vol. 38, Nos. 8–9 (2019), 1800106; Hanusha Bhakhoa, Lydia Rhyman, and Ponnadurai Ramasami, “Theoretical Study of the Molecular Aspect of the Suspected Novichok Agent A234 of the Skripal Poisoning,” Royal Society Open Science, Vol. 6, No. 2 (2019), p. 181831.

7 Steven L. Hoenig, Compendium of Chemical Warfare Agents (New York: Springer Science and Business Media, 2007), pp. 79–88; D. Hank Ellison, Handbook of Chemical and Biological Warfare Agents (Boca Raton, FL: CRC Press, 2007), pp. 37–42.

8 Costanzi and Koblentz, “Controlling Novichoks after Salisbury.”

9 Mirzayanov, State Secrets.

10 Costanzi and Koblentz, “Controlling Novichoks after Salisbury”; Giovanna Pontes, Julieta Schneider, Peter Brud, Lucas Benderitter, Bernhardt Fourie, Cheng Tang, Christopher M. Timperley, and Jonathan E. Forman, “Nomenclature, Chemical Abstracts Service Numbers, Isomer Enumeration, Ring Strain, and Stereochemistry: What Does Any of This Have to Do with an International Chemical Disarmament and Nonproliferation Treaty?” Journal of Chemical Education, Vol. 97, No. 7 (2020), pp. 1715–30; “Chemistry and Diplomacy,” Pure and Applied Chemistry, Vol. 90, No. 10 (2018), pp. 1507–25.

11 Jean Pascal Zanders, “The Chemical Weapons Convention and Universality: A Question of Quality over Quantity?,” Disarmament Forum, No. 4 (2002), pp. 23–31.

12 OPCW, “Recommendation for a Change to Schedule 1 of the Annex on Chemicals to the Chemical Weapons Convention,” EC-M-62/DEC.1, January 14, 2019, <www.opcw.org/sites/default/files/documents/2019/01/ecm62dec01%2B%28e%29.pdf>.

13 (US) Federal Register, “Impact of Proposed Additions to the ‘Annex on Chemicals’ to the Chemical Weapons Convention (CWC) on Legitimate Commercial Chemical, Biotechnology, and Pharmaceutical Activities Involving ‘Schedule 1’ Chemicals (Including Schedule 1 Chemicals Produced as Intermediates),” Vol. 84, No. 157 (2019), <www.govinfo.gov/content/pkg/FR-2019-08-14/pdf/2019-17256.pdf>.

14 Ellison, Handbook, pp. 105–39.

15 OPCW, “Summary of the Third Meeting of the Scientific Advisory Board Temporary Working Group on Investigative Science and Technology,” SAB-28/WP.3, June 4, 2019, pp. 10–11, <www.opcw.org/sites/default/files/documents/2019/06/sab-28-wp03%28e%29.pdf>.

16 Costanzi and Koblentz, “Controlling Novichoks after Salisbury”; Costanzi and Koblentz, “Updating the CWC.”

17 OPCW Technical Secretariat, “Note by the Technical Secretariat: Consolidated Text of Adopted Changes to Schedule 1 of the Annex on Chemicals to the Chemical Weapons Convention,” S/1820/2019, December 23, 2019, <www.opcw.org/sites/default/files/documents/2019/12/s-1820-2019%28e%29.pdf>.

18 Costanzi and Koblentz, “Controlling Novichoks after Salisbury”; Stefano Costanzi, Charlotte K. Slavick, Brent O. Hutcheson, Gregory D. Koblentz, and Richard T. Cupitt, “Lists of Chemical Warfare Agents and Precursors from International Nonproliferation Frameworks: Structural Annotation and Chemical Fingerprint Analysis,” Journal of Chemical Information and Modeling, Vol. 60, No. 10 (2020), pp. 4804–16.

19 Costanzi and Koblentz, “Controlling Novichoks after Salisbury.”

20 Mirzayanov, State Secrets, p. 145.

21 OPCW Technical Secretariat, “Request for Technical Assistance by Germany.”

22 Costanzi et al., “Lists of Chemical Warfare Agents.”

23 Costanzi et al.

24 Stefano Costanzi, Gregory D. Koblentz, and Richard T. Cupitt, “Leveraging Cheminformatics to Bolster the Control of Chemical Warfare Agents and Their Precursors,” Strategic Trade Review, Vol. 6, No. 9 (2020), pp. 69–92.

25 Costanzi et al., “Lists of Chemical Warfare Agents.”

26 Allan E. Sherr, Catalysts for curing polyepoxides, US Patent 3,308,094, filed November 8, 1962, and issued March 7, 1967; Akifumi Fujitani, Yoshihiro Suzuki, and Tsuneo Tanuma. Curing epoxy resins, Japan Patent 61,133,228 A, filed November 30, 1984, and issued June 20, 1986.

27 OPCW, “Note by the Director-General: General Request for Information from States Parties on New Types of Nerve Agents,” S/1621/2018, May 2, 2018, <www.opcw.org/sites/default/files/documents/S_series/2018/en/s-1621-2018_e_.pdf>.

28 Costanzi et al., “Leveraging Cheminformatics”; Costanzi et al., “Lists of Chemical Warfare Agents.”

29 Stimson Center, “Cheminformatics,” <www.stimson.org/project/cheminformatics/>.

30 Costanzi and Koblentz, “Controlling Novichoks after Salisbury”; Costanzi and Koblentz, “Updating the CWC”; Costanzi et al., “Lists of Chemical Warfare Agents.”

31 Costanzi et al., “Leveraging Cheminformatics.”

1 Stefano Costanzi et al., “Lists of Chemical Warfare Agents and Precursors from International Nonproliferation Frameworks.”

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