Determination of (S)-(+)-Ibuprofen Using Enantioselective, Potentiometric Membrane Electrodes Based on Macrocyclic Antibiotics

Abstract

The enantioselective, potentiomeric membrane electrode based on vancomycin and teicoplanin modified with acetonitrile were proposed for the assay of (S)-(+)-ibuprofen. The linear concentration ranges for the proposed enantioselective membrane electrodes were 10⁻² to 10⁻⁴ and 10⁻² to 10⁻⁶ mol/Lfor electrodes based on vancomycin and acetonitrile modified teicoplanin, respectively, with slopes of 58.5 and 57.0 mV/decade of concentration, respectively. The proposed electrodes could be employed reliably for the assay of (S)-(+)-ibuprofen raw material and in its pharmaceutical formulations, Myprodol capsules and Nurofen tablets. The surfaces of the electrodes are stable and easily renewable by polishing on alumina paper.

Keywords:

• Enantioselective
• Potentiometric membrane electrode
• (S)-(+)- Ibuprofen
• Teicoplanin
• Vancomycin

Notes

All measurements were made at room temperature; all values are average of ten determinations.