64
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

Determination of (S)-(+)-Ibuprofen Using Enantioselective, Potentiometric Membrane Electrodes Based on Macrocyclic Antibiotics

, , &
Pages 197-203 | Received 30 Oct 2008, Accepted 07 Dec 2008, Published online: 11 Mar 2009
 

Abstract

The enantioselective, potentiomeric membrane electrode based on vancomycin and teicoplanin modified with acetonitrile were proposed for the assay of (S)-(+)-ibuprofen. The linear concentration ranges for the proposed enantioselective membrane electrodes were 10−2 to 10−4 and 10−2 to 10−6 mol/Lfor electrodes based on vancomycin and acetonitrile modified teicoplanin, respectively, with slopes of 58.5 and 57.0 mV/decade of concentration, respectively. The proposed electrodes could be employed reliably for the assay of (S)-(+)-ibuprofen raw material and in its pharmaceutical formulations, Myprodol capsules and Nurofen tablets. The surfaces of the electrodes are stable and easily renewable by polishing on alumina paper.

Notes

All measurements were made at room temperature; all values are average of ten determinations.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 804.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.