The psychometric properties of the PROMIS® profile CAT in people with stroke

ABSTRACT

Background

The Patient-Reported Outcomes Measurement Information System® (PROMIS) Profile Computer Adaptive Testing (CAT) consists of seven CATs and one single item measuring most relevant aspects of health-related quality of life (HRQoL). The aim of our study was to determine construct validity and floor and ceiling effects of the PROMIS Profile CAT in Dutch people with stroke.

Methods

People with stroke receiving rehabilitation completed the PROMIS Profile CAT and the EuroQol-5 dimensions (EQ5D). Construct validity was evaluated with hypotheses testing based on expected correlations between the profile domains and the domains of the EQ5D. The proportion of participants with the lowest and highest scores were calculated for each profile domain to assess floor and ceiling effects.

Results

160 participants were included (median age 61 years, 41.9% female). For the PROMIS Profile domains Physical Function, Anxiety, Depression, Sleep Disturbance, Pain Interference, and Pain Intensity > 75% of the results met our hypotheses. For Fatigue and Ability to Participate in Social Roles and Activities only 60% of hypotheses were met. No floor or ceiling effects were found, with the exception of a floor effect for Pain Intensity which probably indicates that many participants had no pain.

Conclusion

Most domains of the PROMIS Profile CAT showed sufficient construct validity and no problematic floor or ceiling effects in people with stroke. These CATs and the single item Pain Intensity can be used to efficiently measure HRQoL in people with stroke.

KEYWORDS:

• PROMIS®
• quality of life
• patient-reported
• validity
• measurement properties
• stroke

Disclosure statement

CB Terwee is past president of the PROMIS Health Organization and head of the Dutch-Flemish PROMIS National Center.

Author contributions

Daniëlla Oosterveer, Winke van Meijeren-Pont, Henk Arwert and Thea Vliet Vlieland contributed to the study conception and design. Data collection and analysis were performed by Daniëlla Oosterveer and Winke van Meijeren-Pont. The first draft of the manuscript was written by Daniëlla Oosterveer and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Geolocation information

Basalt has several locations in the province of Zuid-Holland in The Netherlands. The two main locations are located in Leiden and The Hague.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.