Implication of sphingosine-1-phosphate signaling in diseases: molecular mechanism and therapeutic strategies

Abstract

Sphingosine-1-phosphate signaling is emerging as a critical regulator of cellular processes that is initiated by the intracellular production of bioactive lipid molecule, sphingosine-1-phosphate. Binding of sphingosine-1-phosphate to its extracellular receptors activates diverse downstream signaling that play a critical role in governing physiological processes. Increasing evidence suggests that this signaling pathway often gets impaired during pathophysiological and diseased conditions and hence manipulation of this signaling pathway may be beneficial in providing treatment. In this review, we summarized the recent findings of S1P signaling pathway and the versatile role of the participating candidates in context with several disease conditions. Finally, we discussed its possible role as a novel drug target in different diseases.

Keywords:

• Sphingosine-1-phosphate receptor
• signaling
• sphingosine kinase
• cancer
• microbial diseases
• targeting S1P signaling
• drug target

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Indian National Science Academy.