Abstract
The results of numerous studies indicate that cells can become refractory to the detrimental effect of ionizing radiation when previously exposed to a low, “adapting dose”;. This phenomenon has been termed an “adaptive response”; to ionizing radiation. It has been postulated that the induced radioresistance is due to the induction of DNA repair systems which efficiently protect the adapted cells from the effects of a subsequent, high “challenging dose”;. However, a direct proof of this hypothesis is still lacking. The analyzed endpoints include chromosomal aberrations, survival, mutations, genetic instability and DNA damage repair measured by the comet assay. Frequently contradictory results were published by different authors. For example some authors observed a reduced frequency of apoptosis in adapted cells, whereas others reported the opposite. The source of variablity of the adaptive response in human lymphocytes remains unresolved. While there is no doubt that an adapting dose can trigger some protecting mechanisms within the cell it appears that there is no single, universal mechanism of the adaptive response that is valid for all cell types and irradiation conditions.
Notes
Correspondence address: Institute of Nuclear Chemistry and Technology Department of Radiobiology and Health Protection 16 03–195 Warszawa Poland e‐mail [email protected] Tel: +48 22 811 07 36 Fax: +48 22 811 15 32
Pedagogical University, Institute of Biology, Department of Radiobiology and Immunology, ul. Swietokrzyska 15, 25–406 Kielce, Poland
Medical College of Wisconsin 8701 Watertown Plank Road MFRC 6004, Milwaukee, WI 53226, USA e‐mail: [email protected] Tel: +1 414 456 4670 Fax: +1 414 266 8677