WATER-TOLERANT AND REUSABLE LEWIS ACID CATALYST FOR THE ONE-POT SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN-2-(1H)-ONES UNDER SOLVENT-FREE CONDITIONS

Abstract

3,4-Dihydropyrimidin-2-(1H)-ones were synthesized in high yields by a one-pot cyclocondensation of an aldehyde, a 1,3-dicarbonyl compound, and urea using copper methanesulfonate (2 mol%) as a recyclable catalyst under solvent-free conditions in short reaction time (1–2 h).

Keywords:

• Biginelli reaction
• copper methanesulfonate
• dihydropyrimidin-2-(1H)-one
• one-pot synthesis

Notes

^a Isolated yield.

^b Reuse of catalyst.

^c Using 40% aqueous acetaldehyde.