1,6-HEXANEDIAMINE METHANESULFONATE: A MILD AND EFFICIENT CATALYST FOR THE TETRAHYDROPYRANYLATION OF ALCOHOLS UNDER SOLVENT-FREE CONDITIONS

Abstract

Various alcohols react with 3,4-dihydro-2 H-pyran under mild conditions using a catalytic amount of 1,6-hexanediamine methanesulfonate. It affords the corresponding tetrahydropyranyl ethers in good yields at a faster rate in the absence of solvent.

Keywords:

• alcohols
• catalyst
• 1,6-hexanediamine methanesulfonate
• protecting group
• solvent-free
• tetrahydropyranylation

Notes

^a The reaction was carried out in 10 mL of solvent.

^b Yields based on the isolated products.

^a Yields based on the isolated pure products and confirmed by comparison with authentic samples (GC, IR, and ¹H NMR).