A PRACTICAL AND GREEN APPROACH TOWARD SYNTHESIS OF 2,4,5-TRISUBSTITUTED IMIDAZOLES WITHOUT ADDING CATALYST

Abstract

A simple, efficient, and inexpensive procedure has been developed for the synthesis of 2,4,5-triaryl imidazoles by a three-component, one-pot condensation of benzil, aldehydes, and ammonium acetate in refluxing ethanol without adding catalyst. The “catalyzed-by-itself” approach shows a new direction in green synthesis of the title products.

Keywords:

• catalyzed by itself
• multicomponent reaction
• one-pot synthesis
• 2,4,5-trisubstituted imidazoles

Notes

^a All reactions were carried out at reflux temperature for 1 hr.