Abstract
The lipophilicities of twelve 3,5‐dioxo‐4‐azatricyclo[5.2.2.02,6]undecanes, potential serotonergic 5‐HT1A receptors antagonists, was determined by means of the reversed‐phase RP‐18W and RP‐18 thin‐layer chromatography. The use of the linear (Soczewinski‐Wachtmeister) and square (Schoenmaker) equation for R MW calculation was evaluated. Due to the rather poor correlation between linear and square R MW values, despite very good correlation coefficients for independent measurements for each solvent system, the results of the RP‐18 measurements and use of the linear equation for the R MW calculation were found to be the most reliable. Their reliability was also confirmed by the best values of F and s. The standardization (for six standards of known lipophilicity – log P) allowed calculation of the experimental lipophilicities (log P EXP ) for compounds investigated.