Comparison of Multiparallel Microfluidic HPLC Instruments for High Throughput Analyses in Support of Pharmaceutical Process Research

Abstract

The Eksigent Express 800 8 channel and the Nanostream Veloce 24 channel microfluidic HPLC systems were compared for their utility in providing high throughput chromatographic analysis to support a growing demand in pharmaceutical process research. Criteria for success are discussed, a comparison of the two instruments is made, and results from a head to head evaluation using a variety of different analyte mixtures are presented.

Keywords:

• Microfluidic HPLC
• Multiparallel
• Pharmaceutical
• Process research

Acknowledgments

We would like to thank F. Mannarino, J.E. Rehm, D.H. DuPont, and D. Rakestraw at Eksigent Technologies, and P. Patel and D. Boyd at Nanostream for their support in this study. We are grateful to RT‐RLC for providing funding to support this research.