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Journal of Liquid Chromatography & Related Technologies Volume 29, 2006 - Issue 20
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Original Articles

Validated Reversed‐Phase HPLC Method for the Determination of Atenolol in the Presence of Its Major Degradation Product

R. Ceresole Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
,
M. A. Moyano Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
,
M. T. Pizzorno Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
&
A. I. Segall Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, ArgentinaCorrespondence[email protected]
Pages 3009-3019 | Received 14 Jul 2006, Accepted 22 Aug 2006, Published online: 07 Feb 2007
 
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Abstract

A reversed‐phase liquid chromatographic (RP‐LC) assay method, developed for the quantitative determination of atenolol in the presence of its degradation products is described. The assay involved an isocratic elution of atenolol in a Waters µBondapak® C18 column using a mobile phase consisting of acetonitrile‐sodium phosphate monobasic (0.08 M, pH 3.0) (10:90, v/v). The flow rate was 1.0 mL/min and the analyte monitored at 284 nm. The assay method was found to be linear from 0.4 to 12.8 µg injected. All the validation parameters were within the acceptance range. The developed method was successfully applied to estimate the amount of atenolol in tablets.

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