Liquid Chromatographic Chiral Separations by Crown Ether‐Based Chiral Stationary Phases

Abstract

Liquid chromatographic chiral stationary phases (CSPs) based on chiral crown ethers have been successfully utilized in the separation of the enantiomers of various racemic compounds containing a primary amino group. Especially, CSPs based on chiral crown ethers incorporating chiral binaphthyl unit or tartaric acid unit have been most successful. In this review, the development of CSPs based on chiral crown ethers incorporating a chiral binaphthyl unit or a tartaric acid unit, their applications to the resolution of various primary and non‐primary amino compounds with the variation of the type and the content of organic, acidic, and inorganic modifiers in an aqueous mobile phase or with a non‐aqueous mobile phase and the efforts to improve the chiral recognition efficiency or the stability of the CSPs have been discussed.

Keywords:

• Chiral separation
• Chiral stationary phase
• Chiral crown ether
• Liquid chromatography

Acknowledgement

This work was supported by a grant from the National Core Research Center (NCRC) Program (Project R15‐2006‐022‐03001‐0) funded by Korea Science and Engineering Foundation (KOSEF).