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Original Articles

Automatic Selection of Mobile Phases. VII. Thin‐Layer Chromatography on Silica and Alumina of 11,12‐Disubstituted trans/cis‐11,12‐Dihydro‐6H‐dibenzo[c,h]chromen‐6‐ones

, , , &
Pages 2155-2169 | Received 23 Oct 2006, Accepted 07 Nov 2006, Published online: 28 Jun 2007
 

Abstract

Fifteen title compounds with four fused rings and two varying substituents were used to further specify the scope and limitation of a theoretical approach (the Snyder theory and LSChrom software) for selection of mobile phases avoiding any trial and error experiments. Based on the structure of the compounds, the theoretical treatment predicted values of strength ϵ of suitable mobile phases for TLC, namely 0.311 for silica and 0.446 for alumina. Sixteen specific mobile phases with such or close values of ϵ were arbitrarily selected from lists prepared by complex calculations. They were used to perform TLC. The data obtained showed that the retentions in all 256 measurements done were above the origin and below the solvent front. Thus, a good agreement between the theoretical and experimental data was established, thus proving a successful application of the approach. The retentions of all compounds and separation of one cis/trans pair depended on the stationary phase, ϵ, and the tuning parameters m and P′ of the mobile phases.

Acknowledgment

The authors are grateful to Prof. Lloyd Snyder for helpful comments and encouragement during the elaboration of both versions of LSChrom.

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