56
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Determination of Ticlopidine in Pharmaceutical Tablets by Flow Injection Analysis Using UV-Detection

, &
Pages 3209-3218 | Received 24 Jun 2008, Accepted 31 Jul 2008, Published online: 22 Oct 2008
 

Abstract

A precise and accurate flow injection analysis method for the quantification of ticlopidine in pharmaceuticals is described. An aqueous carrier stream, which was entirely prepared with water was chosen for the flow injection analysis. The method development was achieved by using a reference standard solution of ticlopidine at 3.19 × 10−6 M concentration, which was prepared in water. The solution was injected into the instrumental system at a flow rate of 1.0 mL·min−1 and signals were detected by a UV detector at 214.2 nm. The calibration curves of TP were linear in the concentration range of 1.59 × 10−6 − 7.99 × 10−5 M. The intra- and inter-assay precision was less than 1.3% relative standard deviation. The method exhibited good linearity with the correlation coefficients close to unity. The limit of detection and limit of quantization concentrations were found to be 8.91 × 10−8 and 2.70 × 10−7 M, respectively. The effects of the tablet excipients were insignificant at the 95% probability level. The calculated tablet contents were around 99%, which is in agreement with the ranges stated by pharmacopoeias.

Notes

SD: Standard deviation, RSD: Relative standard deviation, CL: Confidence limit (p = 0.05).

SD: Standard deviation, RSD: Relative standard deviation, CL: Confidence limit (p = 0.05).

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 583.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.