New Advances in Large-Volume Injection Gas Chromatography-Mass Spectrometry

Abstract

Gas chromatography-mass spectrometry (GC-MS) with large-volume injection (LVI) is a well-known analytical technique with high sensitivity and specificity, which has been widely used in the identification and quantitation of organic compounds, especially at very low concentrations. This review paper summarizes the new advances of LVI-GC-MS since 2000 and includes the currently available large volume injectors and GC-MS techniques, the sample preparation techniques used with LVI-GC-MS, and the applications of LVI-GC-MS in the analysis of trace organic compounds in a variety of sample matrices.

Keywords:

• Gas chromatography
• Large-volume injection
• LVI-GC-MS applications
• Mass spectrometry
• Sample preparation