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Abstract
Five amphoteric piperazynyl fluoroquinolones, which are bases in acidic conditions, and flumequine, which is neutral at a low pH, were analyzed in an RP system on C8 plates with acetonitrile/aqueous acidic mobile phases containing various concentrations of potassium perchlorate. Perchlorate, which is so-called chaotropic ion, i.e., making chaos in solvation shell of analytes, caused the increase in retention of basic fluoroquinolones. The retention increased with the increasing concentration of perchlorate ion in the mobile phase to achieve plateau for the mobile phases containing about 10–20 mM of chaotropic perchlorate.
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