PREDICTION OF THE LIPOPHILICITY OF EIGHT NEW P-TOLUENESULFONYL-HYDRAZINOTHIAZOLE AND HYDRAZINE-BIS-THIAZOLE DERIVATIVES: A COMPARISON BETWEEN RP-HPTLC AND RP-HPLC

Abstract

Using RP-HPTLC and RP-HPLC and a methanol-water mixture as the mobile phase, eight new p-toluenesulfonyl-hydrazinothiazole and hydrazine-bis-thiazole derivatives were studied. The linear correlation between R_Mw, k_W and methanol/water ratios showed high values, for the correlation coefficient R². The chromatographic hydrophobic index ϕ₀ was determined by using intercept and slope, the obtained values ranging between 60 and 98. A good linear correlation was obtained between R_Mw, log k_w, and slope. The log P values were calculated using database (Toronto, Canada). The matrices were formed with R_Mw, log k_w and log P and were subjected to principal component analysis (PCA). The best way to extract information from PCA was graphically, by plotting the obtained matrices. By analyzing the scores, the compounds can be grouped in two: the first group contains three compounds that have a phenyl moiety while the second group comprises other five compounds that contain: methyl, chlor-methyl, acetyl, and ethylic ester.

Keywords:

• Computed Log P
• 8 new compounds
• hydrophobic
• lypophilic
• PCA
• RP-HPTLC and RP-HPLC