REVIEW ON RECENT SEPARATION METHODS FOR DETERMINATION OF SOME FLUOROQUINOLONES

Abstract

Fluoroquinolones (FQs) are among the most important antibacterial agents (synthetic antibiotics) used in human and veterinary medicine. They are employed against all bacterial infections, particularly against urinary tract infections and acute respiratory diseases. In the last decade, there was no review covering all different analytical methods used for the determination of fluoroquinolone antibiotics. The present review presented recently published different electrophoretic and chromatographic methods for determination of seven fluoroquinolones (ciprofloxacin, gatifloxacin, levofloxacin, lomefloxacin, norfloxacin, ofloxacin, and sparfloxacin). Presented applications concern analysis of chosen fluoroquinolones in pure forms, different pharmaceutical formulations, biological fluids, and environmental samples.

Keywords:

• biological fluids
• HPLC methods
• electrophoretic methods
• fluoroquinolones
• pharmaceutical preparations
• TLC methods

Notes

Abbreviations: ACN, Acetonitrile; DAD, Diodarray detector; ESI-TOFMS, Electrospray Ionization-Time of Flight Mass-Spectrometry; Fluor., Fluorescence; GC-MS, Gas Chromatography-Mass Spectrometry; HPLC, High Performance Liquid Chromatography; LC-MS, Liquid Chromatography- Mass Spectrometry; PBS, Phosphate buffered saline; TBAB, Tetrabutylammonium bromide; TFA Trifluoroacetic acid.