THE STUDY OF THE LIPOPHILICITY OF NOVEL ANTIBACTERIAL ACTIVE PYRAZOLE DERIVATIVES CONTAINING A CARBOXAMIDE GROUP

Abstract

The retention behavior of biologically active pyrazoles has been determined using RP-18 TLC and IAM chromatography. The experimental parameters of lipophilicity of the studied compounds were determined and compared with calculated partition coefficients obtained by using of different algorithms. The results of lipophilicity-activity relationships and the selected mathematical models (MLR) indicate the important role of lipophilicity in the antibacterial activity of the group of the compounds under consideration.

Keywords:

• activity
• antibacterial
• carboxamide
• chromatography
• lipophilicity
• pyrazole

Notes

The theoretical partition coefficients were calculated by:.

1. ALOGPS program, version 2.1. (Alogps, AClogP, AlogP, KowWin, XLogP2).

2. PALLAS program, demo version (Pallas log P).

3. VEGA ZZ program, version 2.2.0 (Vega log P).

4. MOLINSPIRATION program (miLogP).

N, not active; Sa1, Staphylococcus aureus ATCC 25923; Sa2, Staphylococcus aureus ATCC 6538; Se, Staphylococcus epidermidis ATCC 12228; Bc, Bacillus cereus ATCC 10876; Bs, Bacillus subtilis ATCC 6633; Ml -Microccocus luteus ATCC 10240.