THE HPLC APPLIED IN THE SYNTHESIS OF BROMOPENTAFLUOROBENZENE

Abstract

Bromopentafluorobenzene is a very important fine chemical intermediate, which is synthesized from pentafluorobenzoic acid via decarboxylation and bromination in correct order. In this paper the high-performance liquid chromatography (HPLC) method has been applied in the synthesis of bromopentafluorobenzene, the HPLC determination condition has been studied for the first time. The ODS-C₁₈ (4.6 × 150 mm, 5 µm) column was used. The mobile phase was a mixture of acetonitrile–water–trifluoroacetic acid (55:45:0.05). The wavelength of determination was 254 nm. This method is accurate, simple and rapid, and suitable to laboratory and industry.

Keywords:

• bromopentafluorobenzene
• HPLC
• pentafluorobenzene
• pentafluorobenzoic acid
• synthesis
• the first time

ACKNOWLEDGMENT

This work was supported by the Doctor Foundation of Zhanjiang Normal University (No. ZL0701).

Notes

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