194
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

Selective Sorption and Determination of Atenolol in Pharmaceutical and Biological Samples by Molecular Imprinting Using New Copolymer Beads as a Functional Matrix

, , &
Pages 222-228 | Published online: 10 Oct 2014
 

Abstract

A molecular imprinting polymer (MIP) based on free-radical polymerization was prepared with allyl glycidyl ether/iminodiacetic acid as functional monomers and copper ion-atenolol as the template. The imprinted polymer was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, elemental analysis, and scanning electron microscopy. The MIP of agglomerated micro-particles with multipores was used for solid phase extraction (SPE). The imprinted polymer sorbent was selective for the template. The profile of atenolol uptake by the sorbent reflects good accessibility of the active sites in the imprinted polymer sorbent. In addition, the equilibrium adsorption data of atenolol by MIP were analyzed by isotherm models. The MIP–SPE was the most feasible technique for the extraction of atenolol up to 89.9% in the human plasma, up to 96.0% in human urine, and up to 95.3% in tablets where the recoveries were achieved.

Notes

Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/ljlc.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 583.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.