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Journal of Liquid Chromatography & Related Technologies Volume 38, 2015 - Issue 12
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Original Articles

Quantitative Analysis of Pectin in Drug Product by Size Exclusion Chromatography with Indirect Photometric Detection

Shengli MaDepartment of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USACorrespondence[email protected] [email protected]
,
Nelu GrinbergDepartment of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USACorrespondence[email protected] [email protected]
,
Heewon LeeDepartment of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA
,
Keith FandrickDepartment of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA
,
Jane LiDepartment of Material and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA
,
Frank RoschangarDepartment of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA
&
Chris SenanayakeDepartment of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA
 show all
Pages 1254-1258 | Published online: 02 Jun 2015
 
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Abstract

A method for quantitative analysis of pectin in lozenges is reported. The separation was achieved using size exclusion chromatography. While pectin has no chromophore, to detect the separated pectins, an on-column derivatization with phenylboronic added as an additive in the mobile phase followed by indirect photometric detection was employed. The mobile phase, pH, and concentration of the additive were investigated to develop the optimal method with good linearity (R2 = 0.999). The method was applied to the determination of quantity of pectins in commercial lozenges.

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