Recent trends in impurity profiling and forced degradation of antihypertensive drugs

ABSTRACT

This review describes the recent trends in analytical perspectives of impurity profiling and forced degradation of pharmaceutical drug and drug products used for the treatment of hypertension. Hypertension classes include diuretics, angiotensin receptor blocker, β adrenergic blocker, calcium channel blocker. Description based on use of various chromatographic methods, stationary phase, column, detectors are mentioned. Recent advancement in the field of impurity and stability study are focused on drugs belonging to these categories.

GRAPHICAL ABSTRACT

KEYWORDS:

• Analytical perspectives
• forced degradation study
• hypertension
• impurity profiling
• recent advancement
• regulatory guidelines