Impregnated silica-based layers in thin layer chromatography

Abstract

Impregnated thin-layer chromatography (TLC) layers based on silica gel are presented. Impregnating agents such as metal cations, inorganic ions, chelating agents, chiral selectors, surfactants, ion-pairing reagents, and ionic liquids are discussed. The role of impregnated TLC layers in medicinal chemistry is highlighted. The historical overview of TLC separations on physically coated layers is given and some future prospects ahead of this technique are discussed.

GRAPHICAL ABSTRACT

Keywords:

• Thin layer chromatography
• impregnated stationary phases
• chiral impregnating agents
• lipohilic impreganting agents
• surfactant-modified phases
• bioavailability studies

Acknowledgements

Special thanks are due to Professor Elżbieta Brzezińska for her constant support and encouragement.

Additional information

Funding

This work was supported by Medical University of Lodz, Poland [Grant number 503/3-016-03/503-31-001].