Protein chromatography by molecular imprinted cryogels

Abstract

Molecularly imprinted cryogels for protein recognition have received much attention in recent years with the development of supermacroporous polymer systems. Molecularly imprinted cryogels, which offer great advantages for the selective and effective purification and separation of biomacromolecules from their sources, have become an important candidate for affinity matrix. Cryogels with their macroporous structure give rise to use them in different applications, such as tissue engineering, protein recognition and separation fields and environmental issues. This review highlights the principles of molecular imprinting technology, the preparation and properties of cryogels, the recent developments and applications of molecularly imprinted cryogels especially in protein chromatography.

Graphical Abstract

Keywords:

• Cryogel
• molecular imprinting
• protein
• purification
• separation