Direct Chromatographic Resolution of Racemic Pyridoglutethimide Using Two Cellulose-Based Chiral Stationary Phases

Abstract

Enantiomeric separation of racemic pyridoglutethimide by direct liquid chromatographic method was accomplished using Chiralcel OD and Chiralcel OJ columns without any derivatizations. Maximum resolution (R) ot 0.96 was obtained for the enantiomers of pyridoglutethunide using Chiralcel OD column while maximum resolution (R) of 1.56 was obtained using Chiralcel OJ column.