Role of Solvents in the Resolution of Some Beta-Adrenergic Blockers on Cellulose 3, 5-Dimethylphenyl Carbamate Chiral Stationary Phase

Abstract

The steroselective resoulation of racemic- mixture of seven beta-adrenergic blockers were achieved on cellulose 3, 5-diemethylphenyl carbamate chiralstationary phase (Chiralcel OD). The role of the mobile phase solvents in the resolution of these beta-blockers namely, tertalolol oxpernolo, p-oxprenolo, alprenolo, acebutolol, bisoprolol and tolamolol were presented. It was found that it is not essential to add diethylamine as a suppressor in the mobile phasse to effect the separation of the recemate to their corresponding enantimers. However addition of diethylamine improved the symmetry and sparpness of the peaks. The chiral recognition mechanism(s) of this phase is discussed.