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Abstract
A simple and rapid isocratic enantiomeric separation of several racemic drugs with two stereogenic centers, namely for-moterol, labetalol, nadolol, indenolol, and U-54494A, was achieved under normal phase mode using a urea-type chiral stationary phase (CSP) column of (S)-indoline-2-carboxylic acid and (R)-1-(α-naphthyl) ethylamine, known as Chirex 3022 column. Labetalol and formoterol were resolved successfully into its four enantiomers. Furthermore, racemate mixture of U-54494A has been resolved into its individual enantiomers. However, nadolol and indenolol was partially separated.
