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Pharmaceutical Development and Technology Volume 25, 2020 - Issue 1
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Research Articles

Soluplus®/TPGS mixed micelles for co-delivery of docetaxel and piperine for combination cancer therapy

Yanfang DingSchool of Basic Medicine, Dalian Medical University, Dalian, PR China; View further author information
,
Yingying DingSchool of Pharmacy, Dalian Medical University, Dalian, PR China; View further author information
,
Yutong WangSchool of Pharmacy, Dalian Medical University, Dalian, PR China; View further author information
,
Changyuan WangSchool of Pharmacy, Dalian Medical University, Dalian, PR China; View further author information
,
Meng GaoSchool of Pharmacy, Dalian Medical University, Dalian, PR China; View further author information
,
Youwei XuSchool of Pharmacy, Dalian Medical University, Dalian, PR China; View further author information
,
Xiaodong MaSchool of Pharmacy, Dalian Medical University, Dalian, PR China; View further author information
,
Jianping WuSchool of Pharmacy, Dalian Medical University, Dalian, PR China; View further author information
&
Lei LiSchool of Pharmacy, Dalian Medical University, Dalian, PR China; ;Key Laboratory for Basic and Applied Research on Pharmacodynamic Substances of Traditional Chinese Medicine of Liaoning Province, Dalian Medical University, Dalian, PR ChinaCorrespondence[email protected]
View further author information
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Pages 107-115 | Received 12 Apr 2019, Accepted 09 Oct 2019, Published online: 27 Oct 2019
 
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Abstract

In this study, mixed micelles of Soluplus® and TPGS were developed for co-administering docetaxel (DTX) and piperine (PIP) for exerting the synergistic effect, which increased the cytotoxicity and improved the anti-cancer activity in HepG2 cell lines compared to free DTX. These in vitro (MTT assay, intracellular uptake of micelles) and in vivo (pharmacokinetic study, immunostaining, TUNEL analysis) studies exhibited the advantages of co-delivery of anticancer drugs with Soluplus®/TPGS by mixed micelles and furthermore established that co-delivery of DTX and PIP via the mixed micelles of Soluplus®/TPGS could be a promising strategy for the treatment of liver cancer.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (No.81202484 and No.81600527).

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